I've been playing it pretty much non-stop all weekend; I'm about to do the raid on the FIB building. I think the thing that annoys me the most about GTA games is the mission structure and how they drag out each mission as long as humanly possible. Have to cut through a grate with a torch? No cutscene, we'll make you cut each individual little piece of it! Have to wait for someone to come out of a parking garage? Need to scan pedestrians from a helicopter? Look at 10 different people for no reason before you find the one you're looking for! There's just no point 99% of the time. Not to mention the fact that a lot of the later missions make you drive across the whole fucking state multiple times.
"COLONEL KLINK, WHY HAVE YOU FORSAKEN ME?!"