Wow, you would think as good comedian like Chappelle would know how to handle hecklers at this point in his career. Just rip into the hecklers and make them look like the assholes they are like other comedians do.
I remember when I saw George Carlin about 15 years ago and he shut a heckler up real quick. George came out and started his set and some guy shouted some stuff at him a couple times. Both times Carlin asked him nicely to be quite but when they guy interrupted a third time Carlin said "would somebody shove a dick in that guys mouth so he shuts the fuck up?" That line got huge laughs from the audience and the guy didn't say anything for the rest of the show. Now, that's how you handle a heckler.