I don't like shooters so there goes most people's favorites for me.
In my opinion, the best games ever made are Pokemon Blue/Red/Yellow and Red Dead Redemption. And that doesn't account for sports games, which make up 90% of my lifetime accumulation of gaming. NBA 2K11, which I'm playing on Saturday and getting for my birthday later this month, is supposed to be in the argument for best sports game ever, and based on everything I've read and videos I've seen, I think I'll be inclined to agree.
Mortals are mortar and life is the fuse.